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The significance of glutamine for cell metabolism is proven by its role also in pathological conditions: cancer cells, in fact, have a special need for amino acids, such as glutamine, arginine and leucine which are those mainly required as reported in Section “Glutamine transporters in human pathology.” From the depicted scenario it emerges that the processes of glutamine absorption from diet, renal reabsorption and delivery to different tissues are essential and must be well coordinated